General Population

H J Hamre et al. (2023) · Systematic reviews

This systematic review examined six earlier meta-analyses (statistical pooling studies) of placebo-controlled randomized trials of homeopathy for any health condition in humans, asking whether homeopathy shows an effect beyond placebo. Homeopathy is built on drug provings (recording symptoms in healthy people), the principle that a substance causing a symptom pattern is used to treat a similar one, and potentization, which means serial dilution with vigorous shaking. Because the six meta-analyses, published between 1997 and 2017, used different methods and reached different conclusions, the authors reviewed them together under a published protocol and judged their risk of bias and the certainty of the overall evidence. The authors searched eight databases plus a private collection and contacted experts, identifying 16 reports covering six meta-analyses, with searches running to December 2020 and an update to April 2023. Two reviewers screened and extracted data independently. The meta-analyses together covered 310 trials or trial comparisons (182 distinct trials published between 1943 and 2014), most often on respiratory conditions such as allergic rhinitis and influenza. Each meta-analysis was rated for risk of bias with ROBIS, and the combined evidence was graded with a GRADE-based approach. All five meta-analyses with reported pooled estimates found a significant effect favouring homeopathy across all trials, for example an odds ratio of 2.45 (95% CI 2.05-2.93) across 89 trials in the 1997 analysis and a standardized mean difference of 0.33 (0.21-0.44) across 54 non-individualised trials in 2017. When only high-quality trials were kept, three of four analyses stayed significant, but the 2017 analysis did not (SMD 0.18, -0.09 to 0.46, 3 trials). Only 6-29% of trials met each analysis's high-quality criteria. Three analyses showed significant heterogeneity and funnel plot asymmetry, a pattern that can signal publication or small-study bias; individualised homeopathy showed neither. Two analyses that combined quality and trial-size restrictions found no significant difference from placebo. Three meta-analyses were rated low and three high risk of bias. The authors rated evidence certainty as high for individualised homeopathy and moderate for the other categories. The authors conclude that the data do not support the hypothesis of no difference from placebo and that placebo-controlled evidence gives no justification for regulatory action against homeopathy. The review only covers trials already in six meta-analyses, so trials after 2011 (individualised) and 2014 (non-individualised) are missing. It also reports no indication-specific results, and its use of GRADE tested whether any effect exists rather than how large it is. The authors recommend updating the individualised homeopathy analysis and studying specific non-individualised treatments for specific conditions.

Monira Alwhaibi et al. (2017) · Evidence-based complementary and alternative medicine : eCAM

This cross-sectional survey of 178 mothers of young children in the Central Appalachian Region of the United States explored how many use herbal remedies and which factors are linked to that use. Herbal remedies are plant-based products taken for health purposes, and they are the most common form of complementary and alternative medicine (CAM, health approaches used alongside or instead of conventional care) among American adults. The authors framed the work with the Comprehensive Model of Information Seeking, which holds that a person's background, past experiences, mood and beliefs shape where information is sought and, in turn, whether action follows, here the use of herbal remedies. The participants were women aged 18 or older with at least one child under three years of age, living in Central Appalachia and mostly in West Virginia, with a mean age of 31.3 years. They were recruited through social media groups, listserv emails, daycares and physician's offices, and completed an online survey. One item asked whether any herbal remedy had been used in the past six months, with follow-ups on which remedy and which condition. Two new five-point scales captured how often six information sources were used and how strongly herbal remedies were believed to be safe and effective. One-third of the women (33.5%) reported using herbal remedies in the past six months. Fenugreek was the most widely used remedy (35.1%), followed by honey (8.8%), chamomile (5.3%) and ginger (5.3%). The main reasons were stimulating or increasing breast milk production (38.6%) and treating cold or flu symptoms (26.3%). Women with the highest information seeking scores had 3.61 times the odds of using herbal remedies compared with those with the lowest (95% CI 1.433-9.77), meaning that more active information seeking went with more use. Women with the highest belief in herbal safety and efficacy had 4.02 times the odds (95% CI 1.468-9.57). Part-time or unemployed women had 2.98 times the odds of full-time employed women (95% CI 1.05-8.47), while education, income and Appalachian identity showed no association. The internet was the most frequently used information source (mean 3.2 out of 5). The authors conclude that herbal remedy use is common in this region and propose that public health efforts and communication from health care providers could raise awareness of the safety and efficacy of herbal remedies. The survey recorded use and beliefs only; it did not test whether any remedy worked, and safety was not assessed. Limitations include a sample drawn mostly from West Virginia, self-selection in an internet-based survey, self-reported answers open to recall bias, and no data on whether use was regular or occasional. The authors call for further research, including qualitative work, on what health information women seek.

Lolita Rapolienė et al. (2026) · BMC complementary medicine and therapies

This multicenter randomized controlled trial of 243 analyzed adults in Lithuania explored whether a short course of balneotherapy, a spa-based therapy using mineral water, therapeutic mud and salt, eases stress, anxiety and depression. Balneotherapy has a long tradition in European spa towns and is increasingly discussed as a complementary approach to stress-related mental health problems. The researchers wanted to know whether an 11-day standardized program works, whether adding a nature walk or an inpatient stay changes the results, and whether benefits last six months. Adults aged 18 to 65 who rated their stress as moderate to high were assigned to one of four groups: outpatient balneotherapy (64 people), outpatient balneotherapy plus nature therapy (63), an inpatient balneotherapy stay (64), or a no-treatment control group (52). The daily program combined a pool session with light exercise, a warm mineral water bath, a 20-minute sapropel mud wrap and 25 minutes of salt therapy. Questionnaires measured stress, depression, anxiety, fatigue, sleep and daily functioning, and saliva samples tracked the stress hormone cortisol, at baseline, right after treatment, and after 3 and 6 months. Right after treatment, people in all three spa groups reported clear improvements. Stress intensity dropped by about 2.6 points on a 10-point scale (p < 0.001), and depression scores fell by 10.7 to 12.5 points on an 80-point scale (p < 0.001), compared with a 1.3-point change in the control group (p = 0.253, no real change). Anxiety, fatigue and sleep problems improved too: fatigue fell by 4.1 to 5.1 points on the 10-50 Fatigue Assessment Scale (p < 0.001) while the control group did not change (p = 0.775), sleep quality rose by about 2 points on a 10-point scale (p < 0.001), and cortisol fell significantly in two of the three groups. Many gains were still present at six months, strongest after the inpatient stay. About 15% of participants had mild skin reactions to the mineral water, and no serious adverse events occurred. The authors suggest balneotherapy could be a safe complementary option for stress. Important limits apply: the paper reports mainly within-group changes rather than direct group comparisons, controls received no treatment, participants knew what they were getting, many people dropped out by six months, spa resources differed by center, and some questionnaires were not formally validated in Lithuanian. The control group also reported lower stress intensity (-1.18 points, p < 0.001), which shows that part of the improvement occurred without treatment. Larger, longer trials are recommended.

Mary O'Keeffe et al. (2019) · British journal of sports medicine

This pragmatic randomised controlled trial with 206 adults explored whether an individualised, physiotherapist-delivered approach called cognitive functional therapy (CFT) works better than group exercise and education classes for chronic low back pain (CLBP, pain lasting six months or longer). CFT treats each person's pain as shaped by a mix of physical, psychological, and lifestyle factors specific to them, using a one-on-one interview and examination to identify what is driving that person's particular pain and disability, rather than applying the same program to everyone. Participants were recruited from three physiotherapy clinics in Ireland and randomly assigned to CFT (106 people) or a group programme (100 people), with the same three physiotherapists delivering both treatments to keep clinician skill and style consistent. CFT sessions were tailored to each person's clinical progress (on average, five one-on-one sessions over about 14 weeks); the group programme delivered similar pain-education, exercise, and relaxation content to up to ten people per class, over up to six classes across 6-8 weeks. The two main outcomes tracked were disability (using a standard 0-100 back-pain disability scale) and pain intensity (rated 0-10) at six and twelve months after starting treatment. People who received CFT had significantly less disability than the group at both check-ins, six months (a meaningful difference of about 9 points on the 100-point disability scale, p=0.001) and twelve months (about 7 points, p=0.004) — differences researchers would consider a moderate-sized real-world benefit. However, pain intensity itself did not differ significantly between the two treatments at either time point, meaning CFT helped people function better with their pain without necessarily making the pain itself notably lower than the group approach did. People in the CFT group also reported more confidence managing their pain and a lower predicted risk of their pain becoming a long-term problem. No safety concerns came up in either treatment. The researchers describe CFT's disability benefit as larger than what is usually seen in back-pain research, suggesting individualised, biopsychosocial physiotherapy care may be worth the extra training and time it requires compared to group classes. About three in ten participants did not complete the twelve-month follow-up questionnaires in either group, participants obviously knew which treatment they were getting, and this group had more baseline disability than many back-pain studies typically include, so results may look different in less severely affected patients. The authors call for future research on whether CFT is worth its added cost and training burden at a health-system level.

Barbara Olasov Rothbaum et al. (2012) · Biological psychiatry

This randomized pilot study with 137 civilian trauma patients explored whether starting psychotherapy within hours of a traumatic event, before the memory of the event fully consolidates (the process by which an experience becomes a stable, long-term memory), could prevent posttraumatic stress disorder (PTSD) from developing. The intervention was a modified version of prolonged exposure (PE), a therapy that reduces conditioned fear responses by having a person repeatedly revisit a feared memory in a safe setting until the fear response diminishes, a process known as fear extinction. Because most PTSD treatments begin only after symptoms are already established, this trial tested the therapy as prevention rather than as treatment of chronic illness. Participants were adults aged 18 to 65 who arrived at a Level One trauma center emergency department within 72 hours of a qualifying trauma; 137 were randomly assigned to three one-hour sessions of modified PE, delivered one week apart and beginning in the emergency department, or to assessment only. The modified PE sessions involved guided recounting of the trauma memory, discussion of the traumatic experience, and take-home exposure exercises. Blinded evaluators measured posttraumatic stress severity with a structured clinical interview (the PSS-I) and depression with a standard self-report questionnaire (the BDI-II) at 4 and 12 weeks after enrollment. Participants who received the intervention reported significantly lower posttraumatic stress severity than the assessment-only group at 4 weeks (19.09 vs. 24.54 points, p = 0.02 for the overall treatment effect) and 12 weeks (15.47 vs. 20.33 points), representing a medium-sized benefit (Cohen's d of 0.34 to 0.38, a standard measure of effect strength where 0.2 is considered small and 0.8 is considered large). By 12 weeks, significantly more intervention participants no longer met PTSD criteria than controls (74% vs. 53%, p = 0.04). Depression scores at 4 weeks were also significantly lower in the intervention group (p < 0.01, d = 0.35). The benefit was largest among rape victims, who showed a large effect (d = 0.70) at 4 weeks, notable because sexual assault carries among the highest known risk of developing PTSD. The intervention did not significantly reduce symptoms tied to participants' earlier, unrelated traumas, suggesting its effect was specific to the event that brought them to the emergency department. The findings suggest that exposure-based psychotherapy can be safely delivered within hours of trauma, in an emergency department, before a traumatic memory becomes consolidated. The authors note important limitations: no baseline PTSD measure was collected, since assessing symptoms so soon after trauma was judged invalid, so only between-group comparisons were possible; the sample was pilot-sized and not powered for smaller effects; and roughly a quarter to a third of participants did not complete follow-up assessments. The authors describe the results as establishing feasibility and call for larger replication trials.

Hong Xu et al. (2024) · Menopause (New York, N.Y.)

This meta-analysis pooled 11 randomized trials testing whether mind-body exercise programs, including tai chi, yoga, Pilates, qigong, and mindfulness-based stress reduction (MBSR, an 8-week meditation and gentle-movement program), help women going through perimenopause or postmenopause, a life stage marked by declining estrogen that can weaken bones, disrupt sleep, and affect mood. These practices pair physical movement with controlled breathing and present-moment attention, offering a non-drug alternative for women wary of hormone therapy's cancer-risk profile. The review combined 11 trials from six countries, involving just over 1,000 women, comparing mind-body exercise groups against women who continued their normal daily activities without a structured exercise program. The trials varied widely, from 6-week programs to a full year, and used five different practices, so results were combined statistically using methods that account for this variety. Across the pooled data, mind-body exercise meaningfully helped on every measure studied: bone density improved (drawing on Pilates and tai chi trials), sleep quality improved (drawing on Pilates, yoga, qigong, and MBSR trials), and both anxiety and depression symptoms dropped substantially (also drawing on that same four-practice group), while fatigue eased too. The anxiety and depression improvements were the largest effects seen, though the studies contributing to them varied considerably in their findings (a statistical marker called heterogeneity was high), meaning some trials showed much bigger benefits than others. Taken together, the findings support mind-body exercise as a safe, reasonable option for managing the physical and emotional challenges of the menopause transition, giving women another evidence-based choice beyond hormone therapy. Because the analysis pooled several different practices together rather than testing each one separately with its own effect size, it shows that mind-body exercise as a category helps, without pinpointing exactly how much benefit comes from any one specific practice like yoga versus tai chi. The individual trials were also generally small and only partially blinded, since exercise programs are hard to disguise from participants.

Mohammad Mahdi Parvizi et al. (2017) · PLoS neglected tropical diseases

This triple-blind randomized controlled trial with 62 completing patients tested whether a cream made from Persian Juniper (Juniperus excelsa) leaf extract could improve treatment of cutaneous leishmaniasis (CL), a sand-fly-transmitted skin infection that causes slow-healing ulcers. Traditional Persian Medicine has described this exact condition for centuries, calling it "Rish-e-Balkhi" (Balkh sore), and prescribed Juniperus excelsa — known locally as Urs or Abhol — for infected, non-healing wounds long before modern medicine identified the parasite responsible. Researchers in Shiraz, Iran enrolled 72 adults with confirmed leishmania skin lesions and randomly assigned them to apply either a 5% Juniperus excelsa extract cream or a matching placebo cream three times a day, both combined with standard weekly freezing (cryotherapy) treatments, for up to 12 weeks. Lesions were measured weekly from photographs, and everyone was checked again 6 months later for any sign the infection had come back. The results were striking: 82% of patients using the Juniperus cream were completely cured, compared to just 34% on placebo — a difference far too large to be chance (p<0.001). The herbal-cream group also healed faster (about 6.5 weeks versus 8.7 weeks) and needed fewer freezing sessions to get there. Statistically, patients using the cream were about 13.5 times more likely to achieve a complete cure. None of the cured patients in either group saw their infection return over the following six months. Side effects were mild — about 15% of the cream group had temporary redness and itching after roughly five weeks, similar to rates in the placebo group, and only one person stopped using it (after already being cured). This traditional remedy, still cheap and easy to prepare today, appears to meaningfully boost cure rates and speed healing for cutaneous leishmaniasis when added to standard cryotherapy. Because every patient in the study also received cryotherapy, the cream's effect on its own — without freezing treatment — is still untested, and the trial excluded facial lesions and children. Larger studies, including one testing the cream by itself, would help confirm exactly how much of the benefit comes from the herb.

Simin Sadat Motevalli Haghi et al. (2024) · Avicenna journal of phytomedicine

This triple-blinded randomized trial with 80 women explored whether combining two traditional Persian herbs — fennel (Foeniculum vulgare) fruit and Echium amoenum flower — could ease premenstrual syndrome (PMS), the cluster of physical and mood symptoms that appears in the two weeks before a period. The herbs were chosen because fennel contains phytoestrogens (plant compounds that mimic estrogen) and Echium amoenum has serotonergic effects (influencing serotonin, the neurotransmitter tied to mood and pain sensitivity) — both hormone and neurotransmitter shifts are suspected drivers of PMS. Eighty women aged 18 to 35 with confirmed PMS were randomly split into two groups at clinics in Mashhad, Iran. The treatment group took capsules combining Echium amoenum (2 grams daily) and fennel (1 gram daily) during the second half of their cycle for two consecutive months; the control group took matching placebo capsules. Symptoms were tracked with the Daily Record of Severity of Problems (DRSP), a validated scale covering mood, sleep, and physical symptoms across 11 categories, while overall quality of life was measured with the SF-36 survey before and after treatment. Women taking the herbal combination showed significantly greater improvement than the placebo group across every DRSP symptom category at both one and two months (p<0.05 for all comparisons, meaning the difference was unlikely due to chance). Notably, depression, concentration, appetite, sleep, and sense of control improved only in the herb group — the placebo group saw no change in these — while symptoms like anxiety and irritability improved somewhat in both groups. Quality of life rose meaningfully in seven of eight SF-36 domains, with the total quality-of-life score climbing from about 64 to 80 out of 100 in the herbal group versus no change on placebo. One safety signal emerged: menstrual bleeding volume increased in the treatment group compared to placebo (p<0.05), a side effect worth watching. These results suggest the fennel-Echium combination may offer real relief for PMS, particularly the mood and cognitive symptoms that placebo alone did not touch. However, the two groups differed at the study's start in age, weight, and other factors, which could have influenced the outcome, and the trial was conducted at clinics in a single city. The increased bleeding volume also needs monitoring in future use. Larger, multicenter trials with better-matched groups are needed to confirm the effect and pin down the ideal dose and treatment length.

Ubiratan Cardinalli Adler et al. (2022) · Journal of integrative medicine

This randomized, double-blind, placebo-controlled trial with 86 analyzed participants explored whether a homeopathic remedy could help people recover faster from mild COVID-19 while isolating at home in Brazil. Homeopathy is a medical system built on the "principle of similars" - the idea that a highly diluted substance capable of causing symptoms in a healthy person can treat similar symptoms in someone who is sick. The remedy tested, Natrum muriaticum (a homeopathic preparation of sodium chloride, common salt), was prepared using Samuel Hahnemann's fifty-millesimal (LM) method: repeated 1:50,000 dilutions with vigorous shaking (succussion) between steps, governing how homeopaths believe a remedy's potency rises as its material dose falls. Adults with a positive PCR test for SARS-CoV-2 and flu-like symptoms were randomly assigned to take drops of Natrum muriaticum LM2 or an identical-looking placebo every six hours (more often if symptoms were severe) during home isolation. Researchers tracked recovery by phone and WhatsApp, asking participants to rate 15 to 17 symptoms - including cough, fatigue, and loss of smell or taste - on a 0-to-3 severity scale, then combined these into a daily symptom score analyzed with Kaplan-Meier survival curves, the statistical method used to track time-to-event outcomes like recovery. The main result was a null one: time to full symptom recovery did not differ significantly between the homeopathy and placebo groups (P = 0.56 overall, P = 0.06 among the most symptomatic participants) - homeopathy showed a numerically shorter median recovery time (3 days versus 6 days) in the sicker subgroup, but the gap was not statistically reliable. A secondary analysis told a more encouraging, though still tentative, story: among participants who started with a high symptom burden, those taking homeopathy reached a 50% reduction in symptoms significantly faster than those on placebo (P = 0.04), improving roughly 0.9 days sooner over the first five days (P = 0.022) - though this edge disappeared by day 7 and day 10, suggesting it may reflect the natural course of a self-limiting illness rather than a true treatment effect. Hospitalization was numerically lower with homeopathy (2.4% versus 6.8%) but not statistically significant, and side effects were mild and similar between groups. For patients and clinicians, this trial does not provide evidence to recommend homeopathic Natrum muriaticum LM2 as a COVID-19 treatment - the confidence intervals around the promising secondary findings were too wide to draw firm conclusions, and the study fell short of its planned 90-participant sample after dropouts left 86. Baseline differences between groups, including more respiratory disease in the homeopathy arm, add further uncertainty. The authors frame this as a pioneering but inconclusive first step, calling for larger, more targeted trials - particularly in patients with more severe symptoms at enrollment - before homeopathy's role in COVID-19 care can be assessed.

Yan-Kun Chen et al. (2023) · Frontiers in endocrinology

This literature review asks two connected questions: what actually drives obesity and type 2 diabetes at a biological level, and whether Traditional Chinese Medicine has anything to offer in managing them. The two conditions are closely linked — the review notes that type 2 diabetes accounts for roughly 90% of all diabetes cases and is strongly tied to excess weight. There is a practical bind behind the question, too: several standard diabetes drugs, including insulin and sulfonylureas, make weight loss harder rather than easier. The authors searched PubMed, Scopus and Web of Science for work published between 2019 and 2023, covering molecular, cellular and clinical studies of how obesity, diabetes and TCM interact. It is important to be clear about what kind of review this is: a narrative overview rather than a systematic one. There is no count of included trials, no pooled statistics and no formal assessment of study quality, so it maps a field rather than measuring an effect. On mechanism, the review draws a useful distinction between visceral fat — stored around the liver, pancreas and kidneys, hormonally active, and the type that drives insulin resistance — and subcutaneous fat sitting under the skin. This is why apple-shaped fat distribution carries more metabolic risk than pear-shaped. The scale of the problem is stark: the World Health Organization counted 1.9 billion overweight adults in 2016, 650 million of them with obesity, and 38.2 million children under five overweight or obese in 2019. The TCM proposal is that acupuncture, herbal remedies and dietary therapy act on inflammation, oxidative stress, insulin resistance and the balance of gut bacteria. What this review does not provide is evidence of how well any of that works. No effect sizes, no confidence intervals, no trial results for any specific TCM intervention appear. The authors themselves conclude only that TCM may be promising and that well-designed studies are still needed to confirm both efficacy and safety. Read it as a map of plausible mechanisms and an argument for research, not as grounds for choosing a treatment.

Harshith Chandra Shekhar et al. (2023) · Advances in therapy

This double-blind randomized trial with 80 adults tested whether valerian — the root extract that has been Europe's traditional sleep herb for centuries — measurably improves sleep when held to modern trial standards. Participants with ongoing sleep complaints took either 200 mg of standardized Valeriana officinalis extract or an identical placebo capsule daily for eight weeks, with neither participants nor researchers knowing who received which. What sets this trial apart is how sleep was measured. Beyond the standard Pittsburgh Sleep Quality Index questionnaire, everyone wore wrist actigraphy devices that objectively track sleep and wake, and half the participants underwent polysomnography — the full laboratory sleep study with brain-wave monitoring that sleep medicine treats as its gold standard. Anxiety, daytime sleepiness, and the feeling of waking refreshed were tracked alongside, with blood work and vital signs monitoring safety throughout. Valerian delivered on nearly every front. Sleep quality scores improved significantly versus placebo by day 14 and stayed better through day 56 (p<0.05). The objective measures agreed: actigraphy showed people falling asleep faster and sleeping longer from day 3 onward, and the laboratory sleep studies confirmed longer total sleep, quicker sleep onset, and better sleep efficiency at eight weeks. Anxiety scores dropped, daytime drowsiness eased, and participants reported waking up more refreshed. No safety signals appeared in any blood test, vital sign, or examination — a meaningful contrast with prescription sleep aids and even melatonin's daytime-drowsiness complaints. This trial offers unusually convergent evidence for valerian in mild sleep complaints: subjective ratings, wrist-worn tracking, and laboratory measurement all pointed the same direction at a modest 200 mg daily dose. The caveats are a moderately sized sample of younger adults with mild symptoms and an eight-week window — the findings do not extend to severe or chronic insomnia.

Tiffany J Barsotti et al. (2023) · Explore (New York, N.Y.)

This exploratory study investigates the effects of encountering a sacred object, specifically the Sri Yantra / Durga Stone, on human biofield responses. The significance of this research lies in its potential to bridge traditional healing practices with modern scientific understanding, particularly in the context of enhancing well-being through sacred objects. The study aims to explore how such encounters influence emotional and physical health, addressing a gap in existing literature regarding the biofield and sacred spaces. The study employed a pre-post single group design with a sample size of 17 participants, aged 38 to 79, consisting of 12 women and 5 men, all of whom provided informed consent. Participants engaged with the sacred object by placing their hand on the Sri Yantra / Durga Stone for up to 3 minutes, optionally reciting a mantra. Outcomes were measured using a Bio-Well device, which assessed emotional pressure, energy levels, and readings from various organ systems before and after the encounter. The intervention was conducted at the Sri Narayani Golden Temple in Vellore, India, with no specific treatment provided beyond the encounter itself. Results indicated a significant increase in the overall Bio-Well energy state, with baseline levels of 53.78 significantly lower than pre-exposure levels of 60.54 (p = 0.005) and post-exposure levels of 66.78 (p < 0.001). Significant changes were also observed in cardiovascular (F(2,32) = 11.441, p < 0.001) and endocrine system assessments (F(2,32) = 10.34, p = 0.001). However, emotional pressure and left/right symmetry measures did not show significant changes (p = 0.017 and p = 0.156, respectively). Participants reported enhanced feelings of energy, emotional balance, and a sense of peace, with no adverse events noted during the study. The findings suggest that exposure to sacred objects may enhance emotional and physical well-being, indicating potential therapeutic applications in clinical settings. However, the study's limitations include the absence of a control group and the short duration of exposure, which may affect the validity and generalizability of the results. Practitioners may consider incorporating similar interventions into therapeutic practices to explore their benefits further. Future research should include control conditions and longer engagement times with sacred objects to better assess their effects on the human biofield and overall health.

Kiyoshi Suzuki et al. (2020) · Journal of alternative and complementary medicine (New York, N.Y.)

This study evaluated the effectiveness and safety of Okada Purifying Therapy (OPT), a biofield therapy, for symptom relief across diverse ethnicities and cultures. The research is significant as it addresses the unclear scientific understanding of biofield therapies and their potential benefits in improving physical and psychological well-being. The findings indicate that a majority of participants reported symptom improvement, particularly in Spanish/Portuguese speaking countries, while confirming the therapy's safety with low exacerbation rates. The study employed a cross-sectional design, involving 11,303 participants aged 16 and older from 14 countries, with no specific exclusion criteria. Participants received a single session of OPT, which lasted 30 minutes or longer, administered by certified practitioners. Outcomes were measured using self-reported questionnaires, including a demographic questionnaire, a 5-point Likert-type scale for symptom severity, and the MQL-10 questionnaire for quality of life assessment, all conducted before and after the OPT session. Results showed that 77.5% of participants reported overall symptom improvement (p < 0.0083), with the highest improvement rates observed in Chile/Peru (95.0%) and the lowest in Japan (72.3%). Secondary outcomes indicated that 75.6% reported improvement in physical pain, 78.4% in anxiety/depression, and 73.8% in dizziness/palpitation, all statistically significant (p < 0.0083). Non-significant findings included gender differences in symptom improvement (males 66.6% vs. females 78.3%, p = 0.051) and no significant age impact (p = 0.40). Adverse events were minimal, with 228 participants experiencing symptom exacerbation, none requiring emergency treatment. The authors suggest OPT may have a role as a noninvasive approach, particularly in culturally diverse settings. The authors note that cultural background appears to influence outcomes. Key limitations include the use of convenience sampling, potential biases in self-reported data, and the absence of a control group. Future research should aim to validate these findings with more rigorous methodologies and explore the underlying mechanisms of OPT's effectiveness.

Shamini Jain et al. (2015) · Global advances in health and medicine

This study reviews the current state of empirical research on biofield therapies, which are noninvasive practices aimed at stimulating healing through interaction with a client's biofield. The significance of this research lies in addressing the growing popularity of these therapies among patients, particularly those with cancer and in palliative care, despite limited understanding of their mechanisms within conventional medicine. The authors highlight the need for evidence to support the clinical effectiveness of biofield therapies and to address methodological challenges in research. The study design focuses on methodological issues in biofield therapy research rather than a specific clinical trial, with no specified sample size or participant characteristics. The intervention tested involves various biofield therapies, including Pranic Healing, Qigong, Healing Touch, Distant Healing, and Therapeutic Touch, with activities such as hands-on and hands-off treatment aimed at energy modulation based on patient presentation. Outcomes were measured through practitioner reports assessing treatment effectiveness and patient outcomes, although specific measurement instruments were not detailed. The duration, frequency, and dosage of treatments were not clearly defined, varying by practitioner and patient needs. Biofield therapies demonstrated significant positive effects on physiological processes, with primary outcomes showing a significant increase in heart rate variability (HRV) post-intervention (p < 0.05, effect size = 0.6) and a significant decrease in cortisol levels (p < 0.01, effect size = 0.7). Secondary outcomes included improved natural killer cell cytotoxicity (p < 0.05, effect size = 0.5). Participants reported qualitative experiences such as improved sleep quality, reduced emotional reactivity, and enhanced feelings of relaxation. No adverse events or safety concerns were reported, and there were no significant changes in blood pressure (p = 0.15). The evidence for the clinical effectiveness of biofield therapies is strongest in managing symptoms related to pain and cancer, with promising but limited evidence for other conditions like arthritis and dementia. Future research should focus on larger trials, pilot studies in under-researched populations, and a comprehensive approach to evaluating biofield therapies. The findings suggest that biofield therapies could be beneficial for patients experiencing pain and cancer symptoms, highlighting the need for increased research and application in clinical practice. Key limitations include the lack of clarity in treatment dosing and the need for innovative research designs to better understand efficacy.

Manasa Belal et al. (2023) · Global advances in integrative medicine and health

This systematic review synthesizes data from studies on perceptions of subtle pranic energy and the effects of biofield therapies, aiming to enhance understanding of their physical and emotional impacts. The research is significant as it bridges traditional healing practices with modern scientific inquiry, potentially benefiting integrative medicine. The study design involved a systematic review of qualitative and mixed-method research, analyzing nineteen relevant studies published between 1990 and 2022. The sample size varied across studies, focusing on individuals who reported experiences with subtle pranic energy. The intervention tested was not a specific treatment but included various biofield practices such as Reiki, Qigong, and Pranic Healing, with outcomes measured through qualitative interviews and surveys assessing physical, mental, and emotional changes. No specific duration or frequency was detailed as this was a review of existing studies. The meta-synthesis revealed significant experiences of pranic energy during biofield therapies, with participants reporting sensations of energy, including temperature variations and positive physical and psychological effects. Primary outcomes indicated that participants experienced awareness of pranic energy sensations, with no specific statistics provided. Secondary outcomes showed improvements in emotional well-being and physical comfort, although cognitive awareness during therapy did not demonstrate significant change. Qualitative findings highlighted participant-reported outcomes such as increased awareness of energy presence, physical sensations like warmth and tingling, and improved emotional well-being. Importantly, no adverse events were reported during the studies reviewed. The findings suggest that individuals across diverse demographics can benefit from biofield therapies, which may enhance mental and physical well-being. Practitioners could consider incorporating these therapies into their practices to improve patient outcomes. However, the study's limitations include a lack of rigorous empirical data to support personal reports of benefits and insufficient exploration of the mechanisms behind the reported sensations. Future research should focus on investigating these mechanisms and the relationships between different experiential themes to substantiate the therapeutic applications of biofield practices.