Osteoporosis

Hong Xu et al. (2024) · Menopause (New York, N.Y.)

This meta-analysis pooled 11 randomized trials testing whether mind-body exercise programs, including tai chi, yoga, Pilates, qigong, and mindfulness-based stress reduction (MBSR, an 8-week meditation and gentle-movement program), help women going through perimenopause or postmenopause, a life stage marked by declining estrogen that can weaken bones, disrupt sleep, and affect mood. These practices pair physical movement with controlled breathing and present-moment attention, offering a non-drug alternative for women wary of hormone therapy's cancer-risk profile. The review combined 11 trials from six countries, involving just over 1,000 women, comparing mind-body exercise groups against women who continued their normal daily activities without a structured exercise program. The trials varied widely, from 6-week programs to a full year, and used five different practices, so results were combined statistically using methods that account for this variety. Across the pooled data, mind-body exercise meaningfully helped on every measure studied: bone density improved (drawing on Pilates and tai chi trials), sleep quality improved (drawing on Pilates, yoga, qigong, and MBSR trials), and both anxiety and depression symptoms dropped substantially (also drawing on that same four-practice group), while fatigue eased too. The anxiety and depression improvements were the largest effects seen, though the studies contributing to them varied considerably in their findings (a statistical marker called heterogeneity was high), meaning some trials showed much bigger benefits than others. Taken together, the findings support mind-body exercise as a safe, reasonable option for managing the physical and emotional challenges of the menopause transition, giving women another evidence-based choice beyond hormone therapy. Because the analysis pooled several different practices together rather than testing each one separately with its own effect size, it shows that mind-body exercise as a category helps, without pinpointing exactly how much benefit comes from any one specific practice like yoga versus tai chi. The individual trials were also generally small and only partially blinded, since exercise programs are hard to disguise from participants.

Gustavo F Gonzales (2011) · Evidence-based complementary and alternative medicine : eCAM

This 2012 review looked at maca (Lepidium meyenii), a root vegetable that has grown in the high Andes of Peru and Bolivia for more than 2,000 years, where it has long been used as both food and a traditional fertility remedy. Written by a Peruvian researcher who has studied maca extensively, the review asked a simple question: does the science actually back up maca's traditional reputation? At the time, Peru's maca exports had grown more than fourfold in a decade, making that question increasingly practical. As a review of existing research rather than one new experiment, there is no single group of people or animals studied. The material available here covers the review's introduction, its round-up of reproduction-focused animal experiments, and its closing remarks, and it leans heavily on rat and mouse studies rather than human trials. How maca is prepared matters: traditional use involves boiling the root or extracting it in alcohol, and the review notes that a simple water extract only works after the pulverized root has been boiled first. In male rats, different doses of maca had inconsistent effects on sexual behavior between two studies, but more reliably increased sperm count and movement, an effect strongest with black maca, weaker with yellow, and absent with red. Red maca extract reduced prostate enlargement caused by testosterone treatment in rats and mice, in a dose-related way, likely due to a plant compound called benzylglucosinolate acting at a step after testosterone's usual hormone receptor rather than by lowering testosterone itself. In female animals, maca did not change estrogen levels but did improve embryo survival in mice, and red and black maca protected bone strength in rats whose ovaries had been removed (a standard aging-and-bone-loss model) without acting like estrogen on the uterus. The review's abstract also states that human clinical trials found maca helpful for sexual difficulties and for sperm count and motility, though the specific numbers behind that claim sit in parts of the original article not available in this record. The author concludes that more chemical and mechanistic research is needed, pointing out that macamides (compounds unique to maca) may explain some of its effects on sexual behavior, though extracts with almost no macamides worked too, meaning other compounds are likely involved as well. Because most of what is captured here comes from animal studies rather than human trials, these findings are best read as promising groundwork pointing toward further human research, useful for understanding why maca is traditionally valued, but not as settled clinical guidance for treating any specific condition today.